'Gudgudee' is a comedy that primarily revolves around Ajay Prasad, a naive and easily influenced man who, for the most part, has led an insulated and isolated life. He has been married for several years, and lives in remote India with his wife and a son.
The family receive an invitation to attend a wedding in Bombay. As Mrs. Prasad and their son are unable to attend, Ajay is asked to attend on his own, which he agrees to do.
Upon arrival in Bombay, he is met at the airport by Ravindranath, who welcomes him, and drives him to his apartment, located in a good upper class locality. Much to his surprise and excitement Ajay finds out that his next door neighbor is a single woman, who acts in commercials and short advertisements. In a comedic twist, Ajay decides to indulge in an affair with her, with hilarious results.