On June 6, six women in a close-knit Amish community go into labor and deliver six girls, sparking fears that they could fulfill an ancient prophecy. The prophecy states that six girls will be born on the sixth day of the six month (6-6-6) and that one of them will become the "Devil’s Hand". Out of fear, one mother kills both herself and her daughter shortly after her birth, and the remaining five girls grow up with relative ignorance of the prophecy. As they come closer to their eighteenth birthday, their actions are constantly monitored by the community, especially Elder Beacon (Colm Meaney), who views any ungodly actions as proof that one of them is Satan's minion. This is all made more troubling by the fact that one of the girls, Mary (Alycia Debnam-Carey), has started having terrifying visions that could suggest that she is the Devil's Hand. As tensions rise, a mysterious figure begins to murder the girls one by one.
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