With the East India Trading Company trying to eliminate all the pirates, Barbossa, Will and Elizabeth race to bring back Jack from Davy Jones' Locker and aid his return to the land of the living. Then, led by Captain Jack Sparrow they must face their foes, Davy Jones and Lord Cutler Beckett.
Beckett, now with control of Jones' heart, forms a dark alliance with him in order to rule the seas and wipe out the last of the Pirates. Now, Jack, Barbossa, Will, Elizabeth, Tia Dalma, and crew must call the Pirate Lords from the four corners of the globe, including the infamous Sao Feng, and compel the nine Pirate Lords to convene at Shipwreck Cove to hold the Brethren Court.
The Brethren Court decides to release the goddess Calypso, Davy Jones's damned lover, from the trap they sent her to out of fear, in which the Pirate Lords must combine the 9 pieces that bound her by ritual to undo it and release her in hopes that she will help them fight. With this, all pirates will stand together and make their final stand for freedom against Beckett, Jones, Norrington, the Flying Dutchman, and the entire East India Trading Company. Who will be the ultimate victor?