'Mizhi' revolves around a nameless, deranged woman who wanders into a fictional village by the name of Ithikkara. Homeless and utterly vulnerable, she gets sexually abused and repeatedly raped. When she ends up roaming the streets fully pregnant, the village waits with bated breath to find out who the father of her child is.
Susheela (Sona Heiden), a quarry worker with a golden heart takes the battered girl under her wings. She is ably supported by Vasanthi, a money lender. There are a few other good samaritans as well who aid and assist the homeless woman according to their capacity.
A handsome young school teacher (Sudheesh) falls in love with the girl but will it be possible for her to heal enough to lead a normal life again? The movie is intended to highlight the grave injustices and abuse that befalls vulnerable women in society.