'Silsiilay' is a modern and emotionally-charged romantic drama that primarily revolves around the personal and professional lives of three women.
Zia (Bhumika Chawla), who is a fast rising Bollywood actress, whose live-in relationship with Neel (Rahul Bose). who was instrumental in grooming her for a cinematic career, is on the verge of collapse. She is committed to him and wants a child with him but he does not want any responsibilities. Soon he moves on and finds another girlfriend, leaving her alone and distraught.
Anushka (Riya Sen) is a telephone receptionist who longs to discover tenderness in her relationship with a wealthy suitor Nikhil (Ashmit Patel). Meanwhile, her office colleague, Tarun (Jimmy Shergill), loves her silently. The working girl must decide between the two in a romantic finale that has a twist in the tale.
Rehana (Tabu) is a housewife who must confront the fact that her husband Anwar (Kay Kay Menon) is being unfaithful to her with an air hostess, Preeti (Celina Jaitley).
The three stories are seamlessly move in together into a composite picture, with the women coming together in an act of solidarity.