Interspersed with humour, this romantic comedy follows the life of Ananthan Thampy (Mohanlal), a middle aged man who has decided never to marry in his life. He thinks he will lose all his youthfulness and manly looks if he should get married. His top priorities in life are body building and physique maintenance.
Ananthan Thampy prefers to be a chronic bachelor and hence the title Mr. Brahmachari. Ananthan Thampi is known among his friends as Thampi annan. His two ever-loyal assistants Rajappan and Varadappan support him and his ideals, though secretly in their hearts, they plan to marry their sweethearts.
His father Shekharan Thampy (Nedumudi Venu) and mother Subhadramma (Kaviyoor Ponnamma) are eagerly waiting for the day when their son would re-think and change his stand one day. Ananthan Thampy's sister Nirmala (Bindu Panicker) and her husband Venugopalan Thampi (Jagathy), popularly called VVT, are happy about thampy's decision, since they have an eye on his vast inheritance.
Shekharan Thampy rents out a house owned by him to an elderly lady-teacher Vasumathi, who reaches there on transfer. She has four daughters. The eldest one, Sindhu is already married while the other three, namely, Ganga (Meena), Yamuna and Kaveri, live with their mother.
In a twist of fate, circumstances keep bringing Ananthan Thampi and Ganga together, but will it be enough to convince him to give up his vow of bachelorhood?