After witnessing the unfortunate death of a woman, who was unable to afford hospital treatment, Dr. Ajay Kumar (Akkineni Nagarjuna) cancels his U.S. immigration and instead sets out to work a plan to open a hospital that will be accessible to people who cannot afford treatment in regular hospitals, called "Amma Hospital".
This draws quite an attention, and he becomes popular, especially with two young women, Swetha (Manisha Koirala) and Sub-Inspector Ramya (Ramya Krishna). He falls in love with Swetha and both get married, breaking Ramya's heart in the process. Shortly thereafter much to their delight, Swetha becomes pregnant.
When Swetha discovers a frightening organ-smuggling operation in her hospital while going through a friend's diagnostic report, she calls Ramya. Ramya calls the police for help as Swetha is being attacked, and names the attacker as "Ajay". Swetha eventually succumbs to the attack. The police arrive to find her dead body and arrest Ajay for murder.
It seems that Ajay's motive for killing Swetha was money, as Swetha was a wealthy heiress. Ajay is convicted and sentenced to death. While being transported to prison, the police van meets with an accident and Ajay escapes. The police launch a manhunt for him, but are unable to catch him. Ajay secretly meets with Ramya and tells her that he did not kill Swetha, and he wants her help to catch the real killer